Raw Exemestane powder (107868-30-4) video
Raw Exemestane powder (107868-30-4) Description
Exemestane,brand name Aromasin. It is an Aromatase Inhibitor. The mechanism of action of Raw Exemestane powder is as an Aromatase Inhibitor.It is a steroidal inhibitor of aromatase which effectively blocks estrogen synthesis in postmenopausal women and is used as therapy of estrogen receptor positive breast cancer, usually after resection and after failure of tamoxifen. Exemestane powderhas been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury.
Breast cancer cell growth may be estrogen-dependent. Aromatase (exemestane) is the principal enzyme that converts androgens to estrogens both in pre- and postmenopausal women. While the main source of estrogen (primarily estradiol) is the ovary in premenopausal women, the principal source of circulating estrogens in postmenopausal women is from conversion of adrenal and ovarian androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) by the aromatase enzyme in peripheral tissues. Estrogen deprivation through aromatase inhibition is an effective and selective treatment for some postmenopausal patients with hormone-dependent breast cancer. Raw Exemestane powder is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as “suicide inhibition”. Exemestane powder significantly lowers circulating estrogen concentrations in postmenopausal women, but has no detectable effect on the adrenal biosynthesis of corticosteroids or aldosterone. This reduction in serum and tumor concentrations of estrogen delays tumor growth and disease progression. Raw Exemestane powder has no effect on other enzymes involved in the steroidogenic pathway up to a concentration at least 600 times higher than that inhibiting the aromatase enzyme.
Raw Exemestane powder (107868-30-4) Specifications
|Product Name||Raw Exemestane powder|
|Drug Class||aromatase inhibitor|
|Molecular Weight||296.41 g/mol|
|Monoisotopic Mass||296.178 g/mol|
|Melting Point||155.13 °C|
|Freezing Point||No data available|
|Biological Half-Life||24 hours|
|Solubility||water solubility Non-soluble|
|Application||used to treat breast cancer in post-menopausal women (women who have gone through the menopause).|
What is Raw Exemestane powder (107868-30-4)?
Exemestane powder is a drug used to treat breast cancer in women who have gone through the menopause.
Exemestane/Aromasin powder is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Exemestane is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Exemestane Powder decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.Exemestane is usually not used in women of childbearing age.
How Raw Exemestane powder (107868-30-4) works
Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive. Blocking the effects of these hormones can treat breast cancer.
In women who have had their menopause, oestrogen is mainly produced by changing androgens (sex hormones produced by the adrenal glands) into oestrogens. This process is called aromatisation and happens mainly in the fatty tissues, muscle and the skin. It needs a particular enzyme called aromatase.
Exemestane blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In early breast cancer, taking exemestane can help to stop breast cancer coming back. In advanced breast cancer, the cancer cells may grow more slowly or stop growing completely.
Raw Exemestane powder (107868-30-4) Dosage
The recommended dose of AROMASIN in early and advanced breast cancer is one 25 mg tablet once daily after a meal.
* Adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to AROMASIN for completion of a total of five consecutive years of adjuvant hormonal therapy.
* The treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
Raw Exemestane powder (107868-30-4) benefits
The large IES (Intergroup Exemestane Study) trial was started in 1998 and compared switching to Aromasin after taking tamoxifen for 2 to 3 years to staying on tamoxifen for 5 years. The results have shown that switching to Aromasin powder for 2 to 3 years AFTER taking tamoxifen 2 to 3 years (for a total of 5 years of hormonal therapy medicine) was better than staying on tamoxifen for 5 years for:
* Increasing the time before the cancer comes back in those who experience a recurrence
* Reducing the risk of a new cancer developing in the other breast
for postmenopausal women diagnosed with hormone-receptor-positive, early-stage breast cancer.
It’s possible that the FDA may approve Aromasin powder to be used to reduce risk in high-risk, postmenopausal women who haven’t been diagnosed.
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