isotretinoin powder (4759-48-2) video
isotretinoin powder (4759-48-2)Specifications
|Product Name||isotretinoin powder|
|Brand Name||Claravis, Amnesteem, Absorica, Myorisan, Zenatane, Sotret, Accutane|
|Monoisotopic Mass||300.44 g/mol|
|Melting Point||189-190 °C|
|Boiling Point||462.8±14.0 °C at 760 mmHg|
|Biological Half-Life||10–20 hours|
|Solubility||Soluble in DMSO; ethanol|
|Storage Temperature||0 – 4 C for short term (days to weeks), or -20 C for long term (months)|
|Application||Isotretinoin is used to treat severe recalcitrant nodular acne (a certain type of severe acne) that has not been helped by other treatments, such as antibiotics. Isotretinoin is in a class of medications called retinoids. It works by slowing the production of certain natural substances that can cause acne.|
What is isotretinoin powder (4759-48-2)
Isotretinoin powder also known as 13-cis-retinoic acid, is a medication primarily used to treat severe acne. Rarely, it is also used to prevent certain skin cancers, and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.
How isotretinoin powder (4759-48-2) uses
Isotretinoin powder is used primarily for severe cystic acne and acne that has not responded to other treatments. Many dermatologists also support its use for treatment of lesser degrees of acne that prove resistant to other treatments, or that produce physical or psychological scarring. Isotretinoin is not indicated for treatment of prepubertal acne and is not recommended in children less than 12 years of age.
It is also somewhat effective for hidradenitis suppurativa and some cases of severe rosacea. It can also be used to help treat harlequin ichthyosis, lamellar ichthyosis and is used in xeroderma pigmentosum cases to relieve keratoses. Isotretinoin has been used to treat the extremely rare condition fibrodysplasia ossificans progressiva. It is also used for treatment of neuroblastoma, a form of nerve cancer.
Isotretinoin therapy has furthermore proven effective against genital warts in experimental use, but is rarely used for this indication as there are more effective treatments. Isotretinoin may represent an efficacious and safe alternative systemic form of therapy for recalcitrant condylomata acuminata (RCA) of the cervix. In most countries this therapy is currently unapproved and only used if other therapies failed.
isotretinoin powder (4759-48-2) Dosage
Isotretinoin therapy should be initiated at a dose of 0.5 mg/kg/d for 4 weeks and increased as tolerated until a cumulative dose of 120-150 mg/kg is achieved. Coadministration with steroids at the onset of therapy may be useful in severe cases to prevent initial worsening. Some patients may respond to doses lower than the standard recommendation dosages. A lower dose (0.25-0.4 mg/kg/d) may be as effective in clearing acne as the higher dose given for the same period and with greater patient satisfaction. However, the benefit of prolonged remission is not as great with such therapy as with standard doses. Lower intermittent dosing schedules (1 wk/mo) are not as effective.
Some patients only require one course of oral isotretinoin for complete acne remission, while others require additional courses of isotretinoin therapy. A study found 38% of the patients had no acne during 3-year follow up, and, among the remaining patients, 17% were controlled with further topical therapy, 25% with topical and oral antibiotics, and 20% with second course of isotretinoin. Relapse is more likely in younger or female patients.
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