Raw Tamoxifen Citrate powder (54965-24-1) Manufacturer - Buyaas

Raw Tamoxifen Citrate powder (54965-24-1)

November 8, 2018
SKU: 54965-24-1
5.00 out of 5 based on 1 customer rating
(1 customer review)

Raw Tamoxifen Citrate powder is the citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition,

 


Status: In Mass Production
Unit: 25kg/Drum

Raw Tamoxifen Citrate powder (54965-24-1) video

 

Raw Tamoxifen Citrate powder (54965-24-1) Description

Raw Tamoxifen Citrate powder is the citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC.

Raw Tamoxifen Citrate powder use to the treatment and prevention of estrogen receptor positive breast cancer. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the endometrium.

 

Raw Tamoxifen Citrate powder (54965-24-1) Specifications

Product Name Raw Tamoxifen Citrate powder
Chemical Name Istubal; Tamoxifen,
Brand Name Nolvadex
Drug Class selective estrogen receptor modulator (SERM)
CAS Number 54965-24-1
InChIKey FQZYTYWMLGAPFJ-OQKDUQJOSA-N
Molecular Formula C32H37NO8
Molecular Weight 563.647 g/mol
Monoisotopic Mass 563.252 g/mol
Melting Point  97 °C
Freezing Point No data available
Biological Half-Life The decline in tamoxifen plasma concentrations is biphasic with a terminal elimination half-life of approximately 5 to 7 days. The estimated half-life of N-desmethyl tamoxifen is 14 days.
Color White or off-white powder
Solubility  water solubility 0.000167 mg/mL at 25 °C
Storage Temperature  2-8°C
Application use to the treatment and prevention of estrogen receptor positive breast cancer.

 


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1 review for Raw Tamoxifen Citrate powder (54965-24-1)
  1. 5 out of 5

    :

    The product TAMOXIFEN CITRATE POWDER is very useful.

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