Raw Tamoxifen Citrate powder (54965-24-1) Manufacturer - Buyaas

Raw Tamoxifen Citrate powder (54965-24-1)

November 8, 2018
SKU: 54965-24-1
5.00 out of 5 based on 1 customer rating
(1 customer review)

Tamoxifen Citrate powder is a nonsteroidal agent with potent antiestrogen properties. Anti-estrogens work by blocking the effects of the hormone estrogen in the body. Estrogen may cause the growth of some types of breast tumors. Tamoxifen may block the growth of tumors that respond to estrogen.

 


Status: In Mass Production
Unit: 25kg/Drum

Raw Tamoxifen Citrate powder (54965-24-1) video

 

Raw Tamoxifen Citrate powder (54965-24-1) Description

Raw Tamoxifen Citrate powder is the citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC.

Raw Tamoxifen Citrate powder use to the treatment and prevention of estrogen receptor positive breast cancer. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the endometrium.

 

Raw Tamoxifen Citrate powder (54965-24-1) Specifications

Product Name Raw Tamoxifen Citrate powder
Chemical Name Istubal; Tamoxifen,
Brand Name Nolvadex
Drug Class selective estrogen receptor modulator (SERM)
CAS Number 54965-24-1
InChIKey FQZYTYWMLGAPFJ-OQKDUQJOSA-N
Molecular Formula C32H37NO8
Molecular Weight 563.647 g/mol
Monoisotopic Mass 563.252 g/mol
Melting Point  97 °C
Freezing Point No data available
Biological Half-Life The decline in tamoxifen plasma concentrations is biphasic with a terminal elimination half-life of approximately 5 to 7 days. The estimated half-life of N-desmethyl tamoxifen is 14 days.
Color White or off-white powder
Solubility  water solubility 0.000167 mg/mL at 25 °C
Storage Temperature  2-8°C
Application use to the treatment and prevention of estrogen receptor positive breast cancer.

 

What is Raw Tamoxifen Citrate powder (54965-24-1)?

Tamoxifen is a type of hormone therapy known as a selective estrogen receptor modulator (SERM). One of the brand names for tamoxifen is Nolvadex.

How Raw Tamoxifen Citrate powder (54965-24-1) works

Tamoxifen works by attaching to the estrogen receptors in breast cells so that estrogen cannot bind to them. By preventing the estrogen in the breasts binding to the receptors, tamoxifen slows the growth and reproduction of estrogen-sensitive breast cancer cells.

Tamoxifen Citrate powder is the citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC.

Raw Tamoxifen Citrate powder (54965-24-1) Dosage

Read the Medication Guide provided by your pharmacist before you start using tamoxifen and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth with or without food, usually once or twice daily for 5 years, or as directed by your doctor. Daily dosages greater than 20 milligrams are usually divided in half and taken twice a day, in the morning and evening, or as directed by your doctor. If you are using the liquid, measure the dose carefully using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Dosage is based on your medical condition and response to therapy.

Raw Tamoxifen Citrate powder (54965-24-1) benefits

Tamoxifen is the first choice for premenopausal women and is still a good choice for postmenopausal women who can’t take an aromatase inhibitor.

Tamoxifen can:

  • Reduce the risk of breast cancer coming back by 40% to 50% in postmenopausal women and by 30% to 50% in premenopausal women
  • Reduce the risk of a new cancer developing in the other breast by about 50%
  • Shrink large, hormone-receptor-positive breast cancers before surgery
  • Slow or stop the growth or advanced (metastatic) hormone-receptor-positive breast cancer in both pre- and postmenopausal women
  • Lower breast cancer risk in women who have a higher-than-average risk of disease but have not been diagnosed

Tamoxifen offers other health benefits that aren’t related to treating cancer. Because it’s a SERM, it selectively either blocks or activates estrogen’s action on specific cells. While tamoxifen blocks estrogen’s action on breast cells, it activates estrogen’s action in bone and liver cells. So tamoxifen can:

  • help stop bone loss after menopause
  • lower cholesterol levels

Buy Tamoxifen Citrate powder from Buyaas.com

Cooperate with us, we can do at least:
1. Our products are produced under cGMP and the quality can be tracked.
2. The purity are Guaranteed no less than 98%. COA; HPLC; HNMR test reports can be provided.
3. Our supply ability is very stable and schedule mass production regularly.
4. We have rich experience in serving high-end markets all over the world.
5. Cooperate with our factory directly, you can reduce your cost.

 


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References & product citations

The Ultimate Guide to Nolvadex to treat breast cancer

 

References

  1. Tamoxifen: Beyond the Antiestrogen, By John A. Kellen, page 1-201
  2. John F. Kessler, Greg A. Annussek, HarperCollins, 6 April 1999, 1-208
  3. Tamoxifen, Dr. Titus Marcus, Independently Published, 29thMarch 2019, 1-18
1 review for Raw Tamoxifen Citrate powder (54965-24-1)
  1. 5 out of 5

    :

    The product TAMOXIFEN CITRATE POWDER is very useful.

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