Clomiphene Citrate(Clomid) (50-41-9) video
Clomiphene Citrate(Clomid) (50-41-9) Description
Clomiphene Citratrate is used to treat infertility in women. It works by stimulating an increase in the amount of hormones that support the growth and release of a mature egg (ovulation). This medication is not recommended for women whose ovaries no longer make eggs properly (primary pituitary or ovarian failure).
Clomiphene Citrate is an orally administered, non steroidal, ovulatory stimulant that acts as a selective estrogen receptor modulator (SERM). Clomifene can lead to multiple ovulation, and hence increase the risk of conceiving twins. In comparison to purified FSH, the rate of ovarian hyperstimulation syndrome is low. There may be an increased risk of ovarian cancer and weight gain. Clomifene is capable of interacting with estrogen-receptor-containing tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix. It may compete with estrogen for estrogen-receptor-binding sites and may delay replenishment of intracellular estrogen receptors. Clomifene initiates a series of endocrine events culminating in a preovulatory gonadotropin surge and subsequent follicular rupture. The first endocrine event, in response to a course of clomifene therapy, is an increase in the release of pituitary gonadotropins. This initiates steroidogenesis and folliculogenesis resulting in growth of the ovarian follicle and an increase in the circulating level of estradiol. Following ovulation, plasma progesterone and estradiol rise and fall as they would in a normal ovulatory cycle.
Clomiphene Citrate(Clomid) (50-41-9) Specifications
|Product Name||Clomiphene Citrate(Clomid) (50-41-9)|
|Chemical Name||Clomifene citrate; Clomid|
|Drug Class||selective estrogen receptor modulator (SERM)|
|Molecular Weight||598.089 g/mol|
|Monoisotopic Mass||597.213 g/mol|
|Freezing Point||No data available|
|Solubility||Slightly soluble in water, methanol, chloroform (slightly), and DMSO (10 mM). Insoluble in ether.|
|Application||used to treat infertility in women|