1.What is Pregabalin?
Pregabalin (148553-50-8) is a drug that is mostly sold under the brand name Lyrica in various regions in the world. It’s an anti-epileptic medicine that is also referred to as anticonvulsant. The drug is used to slow down brain impulses that lead to seizures. On the other hand, Pregabalin affects the brain chemicals that send pain signals across the body nervous system. The drug is also used in the medical world to treat different pains caused by various diseases such as nerve pains caused by fibromyalgia, diabetes, and even spinal cord injury pains.
Pregabalin exists capsules, extended-release, or long-acting tablets and also in oral solution (liquid). All Pregabalin forms work in the same way, and your doctor will be the best person to choose the right one for you depending on your condition or what you want to achieve by the end of the dosage cycle. Being an oral drug serves as the best pain drug for many patients who are unconformable with regular injections. The drug also can lead to some severe side effects when overdosed or misused. Make sure you always follow the dosage instructions for better results.
Pregabalin (148553-50-8) can be used together with other medications to aid the treatment of onset seizures in children aged at least four years old and adults too. For many years now, the drug has been playing a vital role in the medical world, making it one of the most potent pain-relieving drug on the market. The drug should only be taken under a doctor’s prescription for better results. However, always make sure you get the Pregabalin from a reliable seller or manufacturer around you.
2.Pregabalin mechanism of action
Pregabalin belongs to an anticonvulsants class of medications. Typically, the drugs in this class work in the same way and are used in the treatment of similar conditions. It’s not yet clear how exactly Pregabalin works, but it’s believed to work through calming down the damaged nerves in the body that lead to seizures or pains. The drug reduces the pains in the body that is caused by various reasons or diseases. Talk to your doctor for more information about Pregabalin.
In the United States of America, Pregabalin has been approved for use in the treatment of diseases such as;
- Post-herpetic neuralgia or pains that occur after shingles
- Diabetic neuropathy pain and
Fibromyalgia is a health condition that involves widespread pains, such as in the muscles, connective tissues, or heightened and painful response to touch. In other parts of the world, like in Europe, Pregabalin is used in the treatment of anxiety disorder, a condition that other medications are used to treat in the United States of America. As mentioned earlier, Pregabalin is also used with other drugs to enhance the results. Doctors can also prescribe the medication to patients with various conditions that can be treated or controlled by the Pregabalin.
Pregabalin dosage depends on the condition under treatment. However, the lowest dosage is 25mg, while the maximum is 600mg per day. Your doctor will set the right dosage for you after examining your condition. Sometimes the medics will advise you to start with low dosages, which can be adjusted with time. In some exceptional cases, your doctor can increase the dosage further. The Pregabalin dosage are as follows;
Adult Diabetic Neuropathy dosage
For immediate-release, the initial dosage is 50mgs that should be taken three times a day. The dose can be increased by your doctor to 100mg to be taken three times a day within the first week, which will be determined by how your body responds to the first dosage. The medical examination is critical to monitor the treatment progress. At this point, the Pregabalin dosage can be stretched to a maximum of 300mg per day, but that should be done with time. Beginners are always advised to start with low dosages to reduce the side effects.
The extended-release will require you to take an initial dosage of 150mg oral dose once per day, and it’s recommended that you take it after the evening meal. Your doctor can increase the dosage to up to the maximum dose of 330mg daily. The increase of dosage can only happen after the doctor examines your progress and your body’s tolerance to Pregabalin. Remember, don’t adjust the Pregabalin (148553-50-8) dosage without your doctor’s guidance. It can lead to severe side effects.
The day that you will be switching the dosage take the usual morning dosage as prescribed by your medic then start the new dosage after your evening meal. Medical studies have revealed that taking high dosages of up to 600mg per day doesn’t provide any additional benefits. Thus, you should stick to the recommended dose. Taking the maximum 300 to 330gm per day is also not recommended since it can lead to dose-dependent effects.
Postherpetic Neuralgia adult dose
Here the dosages are divided into two categories, immediate-release, and extended-release, and they both differ in dosages. For instance, in immediate release, the initial Pregabalin dose is 150mg to 300mg per day, which is divided into two or three prescriptions in a day. Similarly, the dosages can be increased to 300 per day after a few days depending on how your body responds to the initial dosage. If the results are impressive, then the doctor will have no reason to increase it. The medic can also lower the dosage further in case you take the low dosages and experience severe side effects.
After taking the 300mg dosage for about two to four weeks, and the pain relief is insufficient, the doctor can decide to raise it to about 600mgs daily to be taken two or three times a day. Remember, 600mg per day is the highest recommended dosage for all patients. Exceeding this level can lead to severe Pregabalin side effects, which will be hard or costly to reverse.
For the extended-release:
Here, the initial Pregabalin dosage is 165mg that should be taken once per day, and it’s recommended that you take it after the evening meal. There is also a possibility for the dosage to be increased further to 330mg within the first week of dosage cycle. After two or for weeks of medication and there is no significant improvement in the pains then your doctor can raise the dosage to the maximum which 660mgs per day. When switching the dosages, take the morning one for immediate-release then start the extended-release medication after taking your evening meal.
Epilepsy adult dosage
For epilepsy treatment, the initial oral dosage is 150mg per day, which is divided into two or three times. Just like in other therapeutic dosages, the doctor can increase the dose to 600mgs per day and should also be divided to be taken in two or three times a day. Here the maximum dosage is 600mg per day.
The efficiency and effects of this drug are all dependent on the drug’s dosage. No study has proven the importance of combining Pregabalin with gabapentin. However, your doctor will advise you more on what drugs to use together with this drug.
Fibromyalgia adult dose
Here the initial dose is 75mg taken twice a day and can be adjusted to 150mg two times a day within the first week of dosage. The dosage can also be increased further to 225mg to be taken twice a day. The maximum dosage for fibromyalgia is 450mgs and a maintenance dosage of about 300mg to 450mg. On the other hand, studies show that taking 600mgs per day doesn’t offer any additional Pregabalin benefits but can result in severe side effects.
Pregabalin for Neuropathic pain
The initial dose is 75mg per day and can also be increased to 150mg per day. In case, after two or three weeks dosage, there is no significant improvement, then your medic can adjust it upwards to 300mgs. The recommended Maintenance dosage ranges from 150 to 600mg divided dosages per day.
In the medical world, it’s evident that Pregabalin delivers quality and impressive results for users who follow the dosage instructions. Since the first approved the drug in 2004, millions of patients have benefited from Pregabalin especially in managing nerve pains resulting from various diseases such as Epilepsy, Post-herpetic neuralgia or pains that occur after shingles, Diabetic neuropathy pain and Fibromyalgia. Depending on how your body reacts with the Pregabalin, you can expect to enjoy the result within a very short time.
The first few days of dosage gives your doctor the chance to evaluate your progress before deciding on whether to adjust the dosage downwards or upwards. Studies show that you should expect results within the first few days of dosage. Pregabalin is a fast-acting drug, and you should, therefore, expect the pains to be relieved within the early few days of dosage. In case you don’t experience any improvement within the first week of taking your dose, inform your doctor to adjust the dosage for better results. Human bodies are different, and it’s not automatic that you get the results as quick as others will. Also depending on the condition that you are under medication for, the results will vary. Some of the typical Pregabalin results include;
Reduces Nerve pain
Pregabalin is a potent drug when it comes to minimizing pains that result from nerve damage such as peripheral diabetic neuropathy, chemotherapy-induced neuropathic pain, or Fibromyalgia. Different studies show that Pregabalin is the most effective drug in reducing neuropathic pains. The supplement remains effective when used alone or even when combined with other medical supplements.
Enhances quality life for patients with Fibromyalgia
As mentioned earlier, Fibromyalgia is a condition where you suffer from widespread pain. Its symptoms include poor quality of sleep, fatigue, anxiety, depression, joint, and muscle stiffness. The drug helps patients control all these effects.
Reduces Epileptic symptoms
FDA approved Pregabalin (148553-50-8) for the treatment of epilepsy. This drug is recommended for patients with partial epilepsy due to brain injury. It is also used as an adjunctive therapy for people that other anti-epileptic medications have failed to work.
Treatment of anxiety
Although in the United States of America, Pregabalin is not used to lower anxiety levels, in Europe, the drug has proved to be an excellent solution. Pregabalin is said to be used off-label to help in the treatment of anxiety disorder in various parts of the world. There are also some undocumented instances when your doctor can find it necessary to prescribe Pregabalin and still deliver quality results. Both short-term and long-term medical studies demonstrate that this drug can effectively treat moderate to severe anxiety in individuals more so adults.
The secret to quality Pregabalin results is to involve your doctor in the whole dosage process. Don’t adjust the Pregabalin dosage without informing your medic. As much as you can easily purchase the drug from different online stores, don’t start taking it without going for a medical check-up. This drug has been potent in relieving pains caused by various reasons. Some athletes also use Pregabalin to control the muscle pains, and spinal injury pains, which are common due to intensive workouts and competitions.
6.Pregabalin half life
This is a fast acting-drug with an active Pregabalin half life of 6 hours. Therefore, for better Pregabalin results, the dosages should be divided into two or three per day. Being an oral drug, it makes it easy for you to get results since it has a short elimination half-life. Always remember to stick to the dosage instructions given by your doctor. Even if you take the lowest or highest dosage, the half-life of this drug remains the same.
7.Pregabalin side effects
Just like other drugs on the market today, Pregabalin can also expose you to severe side effects if you overdose it. Majority of the Pregabalin side effects are as a result of misuse or sometimes when your body system reacts negatively with the drug. That’s why it’s always advisable to start with low dosages, which can then be adjusted by your medics after monitoring how your body responds to the medication. Some of the most common Pregabalin side effects include;
- Dizziness –sometimes you might experience drowsiness while taking this drug, but it should disappear after some time.
- Vomiting, dry mouth, and headaches are also other widespread side effects that you might experience when taking this drug.
- Many Pregabalin users also complain of increased appetite, which in turn, result in weight gain.
- There are also cases of a lack of muscle coordination, speech problems, and lack of body balance.
All these Pregabalin side effects disappear after some time, but in case they stay longer than expected, you should inform your doctor to help you get a solution before the condition worsens. On the other hand, there are some severe side effects that you should contact your medic immediately you start experiencing them, and they include;
- Vision problems, the moment you begin experiencing double vision, or blurred vision or any changes in your eyesight don’t hesitate, call your doctor immediately.
- Swelling of face, mouth lips, eyes, throat, tongue, neck, or head cases should also be reported immediately.
- Other severe side effects include; blisters, itching, swelling of ankles, lower legs, hands, and arms or chest pains.
The good news is that all these Pregabalin side effects can be controlled if you inform your doctor in time although some conditions will disappear with time when you experience the advanced effects mentioned above don’t continue taking the dosage without informing your medic. Your doctor can decide to stop the dosage if the situation is uncontrollable or suggest an alternative, safer medication for you.
This is a drug that has proved itself to be among the most potent anti-epileptic medicine on the market today. It has been used to relieve neuropathic pains across the world, and in some regions like Europe, it was approved for the treatment of anxiety. There are a lot of benefits that you will enjoy when taking this drug, Pregabalin benefits which are as follows;
Delivers quality results
Medical studies have proved that Pregabalin provides quality results to all its users who follow the dosage instructions. For those using it for neuropathic pains, you can experience improvements even after taking your first dose. Within the first week, you should start experiencing the full results, and that gives the medics the chance to evaluate the medication process. No matter the reason for using Pregabalin, the results are always impressive.
Pregabalin is administered through the mouth, and therefore, there are no injections involved. Thus, it serves as the best medication for users who are uncomfortable with regular injections. You don’t have to worry about any pains, and you can easily accompany this drug with other medicines so long as you inform your doctor.
It has a long half-life
Compared to other oral medications, Pregabalin has a long active life in your body system, which assures you of steady and quality results. Depending on the condition that you are treating with this drug, you will only need to take your dose for about two to three times a day and sometimes once per day after the evening meal.
You can easily buy Pregabalin powder in bulk or just enough for your dosage cycle from various online stores or the nearest pharmacy since it’s legal in many parts of the world. Your doctor will also be the right person to show you where to buy it. This makes it easy for you to purchase and use the drug without any fears of conflicting with the law.
Less severe side effects
Pregabalin exposes you to less severe side effects compared to other anticonvulsants. You will only experience common side effects such as headache, vomiting, among others for the first days of dosage, and they will disappear. On the other hand, if you inform your doctor early enough, the advanced effects can be easily controlled. However, for a better experience, make sure you don’t use or make any dosage adjustments without informing your physician.
Looking at various Pregabalin reviews, it’s clear that many users are satisfied with the results they get after taking the drug. Pregabalin is regularly used as a pain-relieving drug, and it has been receiving positive feedback from a majority of the users. Medical researchers have also filed different findings, and that’s the reason why FDA approved it to be used in the treatment of Epilepsy, Post-herpetic neuralgia or pains that occur after shingles, Diabetic neuropathy pain and Fibromyalgia.
In other parts of the world like in Europe, Pregabalin has been approved for the treatment of anxiety amongst the adults. However, there are also some few reported cases where some users had the worst experience with the drug. Drugs react differently with human bodies, and it’s not automatic that it works for you just because it helped your friend. Other cases of severe side effects have been attributed to overdosing and misuse of Pregabalin.
In summary, this is a great drug when used correctly and for the right reasons. It has helped millions of people suffering from different diseases, as highlighted above. Just like any other prescription drug, you shouldn’t take the Pregabalin unless your doctor recommends it for you. In case you experience side effects also inform your doctor immediately to help you overcome them.
10.Pregabalin for sale
The world is changing, and today, you can buy Pregabalin powder online on our platform at an affordable price. Our website is user-friendly, making it easy for you to maneuver from one product to another as well as make your order within seconds. You can access our website via your smartphone, tablet, or even your laptop. On top of that, we make deliveries across the world and within the shortest time possible. You can buy Pregabalin in bulk or even just enough for your dosage cycle.
We are the leading Pregabalin supplier in the region, and our affordable prices don’t compromise the quality of our products. We offer a variety of quality medical products in our online store. However, we always advise all our customers to ensure that they undergo a medical checkup before they start taking our products. Our medical products can lead to side effects when misused or overdosed. Pregabalin for sale is also available at your nearest pharmacy but make sure you get it from a reliable seller. Not all online or physical medical stores offer quality products.
11.Pregabalin to treat Nerve pain and Anxiety
For many years now, Pregabalin has been essential in the medical world more so in the treatment of nerve pains, commonly known as neuropathic pain. The drug works by controlling the brain chemicals that send signals to your nerves, which in turn reduces the level of pains in your body system. In the United States of America FDA approved Pregabalin for treatment of nerve pains caused by various diseases such as Epilepsy, Fibromyalgia, Post-herpetic neuralgia or pains that occur after shingles and Diabetic neuropathy pain.
However, Pregabalin (148553-50-8) has not been approved for the treatment of anxiety in the US, although there are reports that some users use it off-label to control the condition. In other parts of the world like in Europe, Pregabalin has been accepted in the treatment of anxiety in adults. There are also unconfirmed reports that Pregabalin can be used to control depression. For more information about Pregabalin, contact your doctor or consult with your pharmacist.
Kim, S. C., Landon, J. E., & Solomon, D. H. (2013). Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin, or pregabalin. Arthritis care & research, 65(11), 1813-1819.
Goodman, C. W., & Brett, A. S. (2017). Gabapentin and pregabalin for pain—is increased prescribing a cause for concern?. New England Journal of Medicine, 377(5), 411-414.
Lam, D. M., Choi, S. W., Wong, S. S., Irwin, M. G., & Cheung, C. W. (2015). Efficacy of Pregabalin in acute postoperative pain under different surgical categories: a meta-analysis. Medicine, 94(46).
Baldwin, D. S., Ajel, K., Masdrakis, V. G., Nowak, M., & Rafiq, R. (2013). Pregabalin for the treatment of generalized anxiety disorder: an update. Neuropsychiatric disease and treatment, 9, 883.